(Yicai Global) April 11 -- In a world first, researchers with the Shanghai Institute of Ceramics under the Chinese Academy of Sciences recently published a paper presenting the novel concept of ‘nanocatalytic medicine,’ which is expected to provide a new, low-toxic and effective cancer treatment solution for personalized biomedicine, state media outlet The Paper reported.
Conventional cancer chemotherapy uses highly cytotoxic chemotherapeutic drugs, which kill cancer cells but also inflict grievous damage on normal cells.
If a specific chemical reaction within the tumor tissue can be selectively catalyzed/triggered with non-toxic/low-toxic nanoparticles and a considerable number of specific reaction products produced locally, then it may enable tumor-specific treatment and imaging without significant side effects on normal tissues, thereby controlling the cancer.
This procedure is called nanocatalytic medicine, and differs from traditional models for clinical cancer diagnosis and treatment. Based on the long-term accumulation of and breakthrough research results in this field, the team of researchers proposed this concept for the first time and defined and discussed its essence and application.
The team, comprising researchers Shi Jianlin and Chen Yu, successfully prepared monodisperse magnesium silicide (Mg2Si) nanoparticles, about 100 nanometers in diameter. They respond to the specific microenvironment of tumors and consume much of the oxygen molecules within them. They also obstruct the vascular system and block the supply of external oxygen molecules and nutrients, thus achieving tumor-specific local starvation treatment.