From Visual China

On December 26, the synthetic biology concept stock broke out.

On the news, a breakthrough new technology invented by researchers at the University of Southern California may revolutionize the field of synthetic biology, significantly advancing genetic engineering and promoting medicine, biotechnology, biofuel production and even space. Progress in the field of exploration.

The above new technology is called clonal reprogramming and assembly of tiled natural genomic DNA(CReATiNG), which provides a simpler and more cost-effective method for constructing synthetic chromosomes.

The researchers said that the most striking thing about this study is that rearranging chromosome segments in yeast and changing their growth rate highlights the profound influence of genetic structure on biological function.

New Breakthrough Technologies in Synthetic Biology

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CReATiNG

It is understood that the working principle of CReATiNG is to clone and recombine natural DNA fragments of yeast, allowing scientists to create synthetic chromosomes that can replace the natural counterparts in cells. This innovative technology allows researchers to combine chromosomes between different yeast strains and species, alter chromosome structure, and delete multiple genes at the same time.

CReATiNG provides the opportunity to use natural DNA fragments as the assembly of whole chromosomes, which significantly reduces the cost and technical barriers, can improve the production efficiency of drugs and biofuels, and pave the way for environmental bioremediation methods.

Synthetic biology has attracted much attention and is also based on industry prospects and policy support. According to CBInsights analysis data, the global synthetic biology market will be $5.3 billion in 2019 and is expected to reach $18.9 billion by 2024, with a compound annual growth rate of 28.8 percent. Among them, China, as one of the important markets for global synthetic biology, is expected to exceed $7 billion by 2025.

In terms of policy, Shanghai and other places have introduced policies to support the development of the synthetic biological industry. Public information shows that in early November this year, the General Office of the Shanghai Municipal People's Government issued the "Shanghai Action Plan for Accelerating Synthetic Biological Innovation to Build High-end Biomanufacturing Industry Clusters (2023-2025)", which aims to promote synthetic biological high-end biomanufacturing.

on November 1, Changzhou, Jiangsu, issued "Changzhou measures to support the high-quality development of synthetic biology industry", proposing three major ten measures, referred to as "synthetic biology 10", to recruit and cultivate more than 150 scientific and technological enterprises, and to set up a municipal synthetic biology industry fund with a scale of more than 2 billion yuan, aiming to expand and strengthen the synthetic biology industry and cultivate future emerging industries. It is planned to build Changzhou into a first-class synthetic biological industry innovation highland in the growth triangle by 2027, with the output value of Changzhou synthetic biological industry exceeding 100 billion yuan.

on December 13, "some measures for Hangzhou to support the high-quality development of synthetic biology industry" focuses on three aspects: improving innovative research and development capability, promoting the development of industrial agglomeration, and improving the ecological service system. it will provide financial assistance to synthetic biology innovation research and development, industrialization, construction of characteristic parks and public service platforms, up to 0.1 billion yuan, and strive to realize the coordinated development of synthetic biology "research and development-transformation-industry.

a number of domestic listed companies layout in the field of synthetic biology

Chuanning Biology (301301.SZ) said on the interactive platform on December 26 that the company has entered the pilot stage of several synthetic biology projects, and the company's first synthetic biology project, red myrrh alcohol, has entered the sales stage.

In the field of synthetic biology, Chuanning Biology focuses on health care products raw materials, biological pesticides, high value-added natural products, high-end cosmetic raw materials and other sectors. At present, there are already products such as red myrhexanol and 5-hydroxytryptophan, which will be produced in the synthetic biology base of Gongliu by the end of this year.

synthetic biology industry map, from the billion European think tank, the East China Sea Securities Research Institute

At the same time, Jiabiyou (688089.SH) is developing a variety of cosmetic raw materials such as α-arbutin and icdoine based on the existing synthetic biology technology platform. Jincheng Pharmaceutical (300233.SZ) has a design capacity of 3000 tons/year of astaxanthin, and its production technology mainly involves the fields of synthetic biology and fermentation engineering technology. Huaxi Biology (688363.SH) developed a group of human collagen raw materials with the help of synthetic biology technology.

In addition, Puli Pharmaceuticals (300630), East China Medicine (000963.SZ), etc. are also accelerating the layout in the field of synthetic biology.

It is worth noting that since the beginning of this year, institutions have frequently investigated listed companies related to synthetic biology. Take Jiabiyou as an example, the reception institutions have been surveyed more than 10 times during the year. In the dragon and tiger list of azure biology and boen group on December 26, institutions also appeared frequently, but they were mostly in the top five selling seats.

( This article starts with titanium media APP, Author Zhang Haixia )